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CD140b Mouse anti-Human, Brilliant Violet 421, Clone: 28D4, BD

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BDB564124 50 Tests
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Catalog No. BDB564124 Supplier BD Biosciences Supplier No. 564124
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Description

Mouse Monoclonal Antibody

Reacts with platelet derived growth factor (PDGF) receptor β , a 170-190 kDa single transmembrane glycoprotein expressed on fibroblasts, smooth muscle cells, glial cells and chondrocytes. PDGF receptors, α and β , are single glycoproteins with intracellular tyrosine kinase domains. They are structurally similar to M-CSF receptor and CD117 (c-kit). Their ligand, PDGF, is a mitogen for connective tissue cells and glial cells. PDGF plays a role in wound healing and acts as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes and neutrophils. Functional PDGF is secreted as a disulfide-linked dimer of A and B chains (PDGF-AA, PDGF-BB or PDGF-AB). Binding of divalent PDGF induces receptor dimerization with three possible forms: αα , αβ , ββ . The PDGF receptor α β and does not cross-react with PDGFR α .

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD140b
Applications Flow Cytometry
Classification Monoclonal
Clone 28D4
Conjugate Brilliant Violet 421
Description PDGF Receptor β chain; PDGFRβ; PDGFRB; PDGFR1; PDGFR; PGFRB; JTK12
Host Species Mouse
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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