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CD141 Mouse anti-Human, PE, Clone: 1A4, BD

Catalog No. BDB559781 Shop All BD Biosciences Products
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BDB559781 100 Tests
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Catalog No. BDB559781 Supplier BD Biosciences Supplier No. 559781
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Description

Mouse Monoclonal Antibody

The 1A4 monoclonal antibody specifically binds to a 75 kDa, a single chain, type I membrane glycoprotein referred to as thrombomodulin and fetomodulin. CD141 is expressed on endothelial cells, smooth muscle cells, epithelial cells, synovial lining cells, and keratinocytes. It is also found on megakaryocytes, dendritic cells, peripheral blood moncytes, and neutrophils, but not on lymphocytes. Reports indicate that CD141 plays an important role in Protein C activation and the initiation of the Protein C anticoagulant pathway. Thrombin loses its procagulant function when it binds to CD141, and the CD141/thrombin complex is able to activate Protein C.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD141
Applications Flow Cytometry
Classification Monoclonal
Clone 1A4
Conjugate PE
Description Thrombomodulin; TM; THBD; THRM; AHUS6; Fetomodulin; BDCA-3
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Purified Human Thrombomodulin
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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