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CD146, Alex-fluor 488 Rat anti-Mouse, Alexa Fluor 488, Clone: ME-9F1, BD

Catalog No. BDB562229 Shop All BD Biosciences Products
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BDB562229 50 μg
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Catalog No. BDB562229 Supplier BD Biosciences Supplier No. 562229

Description

Rat Monoclonal Antibody

The ME-9F1 monoclonal antibody specifically binds to mouse CD146. The CD146 adhesion molecule is a type 1 transmembrane glycoprotein and member of the immunoglobulin superfamily. CD146 is expressed by blood vessel endothelial cells and may play roles in forming intercellular junctions between endothelial cells and influencing the transendothelial migration of other cell types. CD146 is also expressed by some melanoma cell lines, NK cells and neutrophils. CD146 is not detectable on mouse monocytes, dendritic cells, T cells, NKT cells, B cells and smooth muscle cells. Increased expression of CD146 is reportedly associated with NK cell maturation and may be used to characterize different functional NK cell subsets. Activated CD146-positive mouse NK cells reportedly are less cytotoxic and secrete less IFN-γ than their CD146-negative counterparts.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD146
Applications Flow Cytometry
Classification Monoclonal
Clone ME-9F1
Concentration 0.2mg/mL
Conjugate Alexa Fluor 488
Description S-endo 1; S-endo; Muc18; Mcam; Gicerin
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen CBa/J Mouse lymph node Cell Line
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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