CD146, Alex-fluor 647 Rat anti-Mouse, Alexa Fluor 647, Clone: ME-9F1, BD

Rat Monoclonal Antibody

Supplier:  BD Biosciences 562230

Catalog No. BDB562230

Description

The ME-9F1 monoclonal antibody specifically binds to mouse CD146. The CD146 adhesion molecule is a type 1 transmembrane glycoprotein and member of the immunoglobulin superfamily. CD146 is expressed by blood vessel endothelial cells and may play roles in forming intercellular junctions between endothelial cells and influencing the transendothelial migration of other cell types. CD146 is also expressed by some melanoma cell lines, NK cells and neutrophils. CD146 is not detectable on mouse monocytes, dendritic cells, T cells, NKT cells, B cells and smooth muscle cells. Increased expression of CD146 is reportedly associated with NK cell maturation and may be used to characterize different functional NK cell subsets. Activated CD146-positive mouse NK cells reportedly are less cytotoxic and secrete less IFN-γ than their CD146-negative counterparts.

Specifications

• Antigen: CD146
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: S-endo 1; S-endo; Muc18; Mcam; Gicerin
• Host Species: Rat
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Mouse
• Isotype: IgG2a κ

• Applications: Flow Cytometry
• Clone: ME-9F1
• Conjugate: Alexa Fluor 647
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: CBa/J Mouse lymph node Cell Line
• Quantity: 50 μg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.