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CD152 Hamster anti-Mouse, NA/LE, Unlabeled, Clone: 9H10, BD

Catalog No. BDB555278 Shop All BD Biosciences Products
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BDB555278 0.5 mg
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Catalog No. BDB555278 Supplier BD Biosciences Supplier No. 555278

Description

Hamster Monoclonal Antibody

The 9H10 antibody reacts with CD152 (CTLA-4), which is expressed on activated T lymphocytes 2-3 days after stimulation through T cell receptor. CTLA-4 has significant similarity to CD28 in amino acid sequence, structure, and genomic organization. Furthermore, CD152 and CD28 share common B7 family counter-receptors. Unlike CD28, CD152 expression at both mRNA and protein level appears to be restricted to activated T cells with a maximal surface expression between 48 and 72 hours post-activation. The regulation of CTLA-4 protein expression is complex and can involve changes in the rate of transit between intracellular stores and the cell surface. Whereas CD28 delivers a co-stimulatory signal required for T-cell activation, CTLA-4 is a negative regulator of cell-mediated immune responses. CD152 may play roles in induction and/or maintenance of immunological tolerance, regulation of protective immunity, and regulation of some aspects of thymocyte maturation. This hamster mAb to a mouse leukocyte antigen does not cross-react with rat leukocytes.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD152
Applications Flow Cytometry
Classification Monoclonal
Clone 9H10
Concentration 1.0mg/mL
Conjugate Unconjugated
Description CTLA-4
Formulation No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
Host Species Hamster
Immunogen Mouse CTLA-4-human IgG1 fusion protein
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Bovine, Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG2 κ
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For Research Use Only.

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