CD152 Mouse anti-Human, PE, Clone: BNI3, BD

Catalog No.	Quantity
BDB555853	100 Tests

Catalog No. BDB555853 Supplier BD Biosciences Supplier No. 555853

Description

Mouse Monoclonal Antibody

The BNI3 monoclonal antibody specifically binds to the human cytolytic T lymphocyte-associated antigen, CTLA-4. CTLA-4 is transiently expressed on activated CD28+ T cells and binds to CD80 and CD86 present on antigen presenting cells (APC) with high avidity. This interaction appears to deliver a negative regulatory signal to the T cell. There are recent reports that indicate that CTLA-4 is also expressed on B cells when cultured with activated T cells, suggesting a possible role of CTLA-4 in the regulation of B-cell response. Immobilized BNI3.1 antibody enhances T-cell proliferation induced by antibody-mediated crosslinking of CD3 and CD28. Recent studies have shown that CD152 can be expressed by regulatory T (Treg) cells. After cellular fixation and permeabilization, the BNI3 antibody can stain intracellular CD152 expressed in T cells including Treg cells. Clone BNI3.1 was studied in the VI Leukocyte Typing Workshop.

Specifications

• Antigen: CD152
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: BNI3
• Conjugate: PE
• Description: CTLA-4; AILIM; Cytotoxic T-lymphocyte protein 4
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Human CTLA4 Recombinant Protein
• Purification Method: Affinity Purified
• Quantity: 100 Tests
• Regulatory Status: RUO
• Research Discipline: Immunology
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Isotype: IgG2a κ

For Research Use Only.