CD158b Mouse anti-Human, Unlabeled, Clone: CH-L, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 559783

Catalog No. BDB559783

Description

The CH-L monoclonal antibody specifically binds to CD158b proteins. These proteins are 50-58 kDa type I glycoproteins that belong to the killer cell inhibitory receptor (KIR) family. They are also known as CD158b1 (Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2/KIR2DL2; NKAT-6; p58.2); CD158b2 (Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3/KIR2DL3; NKAT-2; p58.2); or CD158j (Killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2/KIR2DS2; NKAT-5; p50.2). CD158b molecules are composed of two extracellular Ig-like domains, a transmembrane region, and either long (76-84 amino acids) or short (39 amino acid) cytoplasmic tails. They are expressed on NK cells and subsets of TCR αβ+ cells or TCR γδ+ cells. Ligand- or CH-L antibody-bound CD158b1 or CD158b2 can reportedly inhibit cytolytic NK and T cell responses to various stimuli including certain target cells expressing MHC class I ligands encoded by HLA-C alleles (Cw 1, 3, 7 and 8). CD158j reportedly may enhance some cellular cytolytic responses.

Specifications

• Antigen: CD158b
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

• Applications: Flow Cytometry
• Clone: CH-L
• Conjugate: Unconjugated
• Host Species: Mouse
• Quantity: 0.1 mg
• Research Discipline: Immunology
• Target Species: Human
• Isotype: IgG2b κ