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CD158b Mouse anti-Human, Unlabeled, Clone: CH-L, BD

Catalog No. BDB559783 Shop All BD Biosciences Products
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BDB559783 0.1 mg
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Catalog No. BDB559783 Supplier BD Biosciences Supplier No. 559783
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Description

Mouse Monoclonal Antibody

The CH-L monoclonal antibody specifically binds to CD158b proteins. These proteins are 50-58 kDa type I glycoproteins that belong to the killer cell inhibitory receptor (KIR) family. They are also known as CD158b1 (Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2/KIR2DL2; NKAT-6; p58.2); CD158b2 (Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3/KIR2DL3; NKAT-2; p58.2); or CD158j (Killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2/KIR2DS2; NKAT-5; p50.2). CD158b molecules are composed of two extracellular Ig-like domains, a transmembrane region, and either long (76-84 amino acids) or short (39 amino acid) cytoplasmic tails. They are expressed on NK cells and subsets of TCR αβ+ cells or TCR γδ+ cells. Ligand- or CH-L antibody-bound CD158b1 or CD158b2 can reportedly inhibit cytolytic NK and T cell responses to various stimuli including certain target cells expressing MHC class I ligands encoded by HLA-C alleles (Cw 1, 3, 7 and 8). CD158j reportedly may enhance some cellular cytolytic responses.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD158b
Applications Flow Cytometry
Classification Monoclonal
Clone CH-L
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C
Isotype IgG2b κ
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