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CD16 Mouse anti-Human, APC-H7, Clone: 3G8, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 560248

Catalog No. BDB560248


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Description

Description

The 3G8 monoclonal antibody specifically binds to the 50-65 kDa transmembrane form of the IgG Fc Receptor (FcγRIII), a human NK cell-associated antigen. CD16 is expressed on NK cells as well as macrophages and granulocytes. Reports indicate that CD16 plays a role in signal transduction and NK cell activation. The 3G8 antibody blocks the binding of soluble immune complexes to granulocytes. The 3G8 antibody is reported (Vossebeld et al., 1997) to increase intracellular calcium levels in human neutrophils by interacting with bothFcγRIIa and FcγRIIIb molecules. This antibody has also been reported to induce homotypic neutrophil aggregation.

Specifications

Specifications

CD16
3G8
APC-H7
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Mouse
IgG1, κ
RUO
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
0.2mg/mL
FcRIII; Fc-gamma RIII; FCG3; FCGR3; FCGRIII; FcγRIII; IGFR3
Affinity Purified
Human polymorphonuclear leukocytes
25μg
Immunology
Primary
Baboon, Cynomolgus, Human, Rhesus Monkey
SDS
Documents
Product Certifications
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