CD172b Mouse anti-Human, PE, Clone: B4B6, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 552602

Catalog No. BDB552602

Description

Reacts with a 50 kDa, type I transmembrane glycoprotein known as signal regulatory protein β (SIRPβ). The SIRPs are members of the immunoglobulin superfamily. SIRPβ does not possess a cytoplasmic domain but instead the transmembrane domain contains a positively-charged residue that interacts with one other transmembrane protein (DAP-12 or KARAP). DAP-12 has two immunoreceptor tyrosine-based activation motifs (ITAM) within its cytoplasmic domain that are thought to link SIRPβ to activating machinery. SIRPβ is expressed on peripheral blood monocytes and granulocytes, but is not expressed on CD34+ cells. SIRPα and SIRPβ have complementary roles in signal regulation and may work together in tuning the response to a stimulus

Specifications

• Antigen: CD172b
• Classification: Monoclonal
• Conjugate: PE
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Immunogen: Human SIRPβ1 extracellular domain Recombinant Protein
• Quantity: 100 Tests
• Research Discipline: Immunology
• Target Species: Human
• Isotype: IgG1 κ

• Applications: Flow Cytometry
• Clone: B4B6
• Description: SIRPB1; SIRP-BETA-1; SIRPβ1; SIRPbeta; SIRP beta
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

For Research Use Only.