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CD172b Mouse anti-Human, PE, Clone: B4B6, BD

Catalog No. BDB552602 Shop All BD Biosciences Products
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BDB552602 100 Tests
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Catalog No. BDB552602 Supplier BD Biosciences Supplier No. 552602
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Description

Mouse Monoclonal Antibody

Reacts with a 50 kDa, type I transmembrane glycoprotein known as signal regulatory protein β (SIRPβ). The SIRPs are members of the immunoglobulin superfamily. SIRPβ does not possess a cytoplasmic domain but instead the transmembrane domain contains a positively-charged residue that interacts with one other transmembrane protein (DAP-12 or KARAP). DAP-12 has two immunoreceptor tyrosine-based activation motifs (ITAM) within its cytoplasmic domain that are thought to link SIRPβ to activating machinery. SIRPβ is expressed on peripheral blood monocytes and granulocytes, but is not expressed on CD34+ cells. SIRPα and SIRPβ have complementary roles in signal regulation and may work together in tuning the response to a stimulus

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD172b
Applications Flow Cytometry
Classification Monoclonal
Clone B4B6
Conjugate PE
Description SIRPB1; SIRP-BETA-1; SIRPβ1; SIRPbeta; SIRP beta
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human SIRPβ1 extracellular domain Recombinant Protein
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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For Research Use Only.

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