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CD18 Rat anti-Mouse, Unlabeled, Clone: M18/2, BD
Rat Monoclonal Antibody
Supplier: BD Biosciences 557437
Description
The M18/2 antibody reacts with the common β 2 chain of LFA-1 (CD11a/CD18, α L β 2 integrin), Mac-1 (CD11b/CD18, α M β 2 integrin), and gp150, 95 (CD11c/CD18, α X β in vivo metastasis of the LB lymphoma to the spleen and that it blocks in vitro formation of aggregates of LB cells and splenocytes. However, other reports indicate that mAb M18/2 has no effect on CTLmediated killing, adherence of C3bi-sensitized erythrocytes to Mac-1, antigen-specific binding of T cells to antigen-producing cells, or rejection of cardiac allografts. Recent in vitro studies indicate that M18/2 antibody stimulates adhesion of Mac-1 to its ligands C3bi and ICAM-1, and it stimulates adhesion of LFA-1 to ICAM-1, but it has no effect upon the interactions of LFA-1 with ICAM-2 nor ICAM-3.

Specifications
CD18 | |
Monoclonal | |
0.5mg/mL | |
Integrin β2 chain | |
Rat | |
Affinity Purified | |
RUO | |
Primary | |
Store undiluted at 4°C |
Flow Cytometry | |
M18/2 | |
Unconjugated | |
Aqueous buffered solution containing ≤0.09% sodium azide. | |
Mouse CTL glycoproteins | |
0.1 mg | |
Immunology | |
Mouse | |
IgG2a κ |
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