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CD18 Rat anti-Mouse, Unlabeled, Clone: M18/2, BD

Catalog No. BDB557437 Shop All BD Biosciences Products
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Catalog No. BDB557437 Supplier BD Biosciences Supplier No. 557437
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Description

Rat Monoclonal Antibody

The M18/2 antibody reacts with the common β 2 chain of LFA-1 (CD11a/CD18, α L β 2 integrin), Mac-1 (CD11b/CD18, α M β 2 integrin), and gp150, 95 (CD11c/CD18, α X β in vivo metastasis of the LB lymphoma to the spleen and that it blocks in vitro formation of aggregates of LB cells and splenocytes. However, other reports indicate that mAb M18/2 has no effect on CTLmediated killing, adherence of C3bi-sensitized erythrocytes to Mac-1, antigen-specific binding of T cells to antigen-producing cells, or rejection of cardiac allografts. Recent in vitro studies indicate that M18/2 antibody stimulates adhesion of Mac-1 to its ligands C3bi and ICAM-1, and it stimulates adhesion of LFA-1 to ICAM-1, but it has no effect upon the interactions of LFA-1 with ICAM-2 nor ICAM-3.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD18
Applications Flow Cytometry
Classification Monoclonal
Clone M18/2
Concentration 0.5mg/mL
Conjugate Unconjugated
Description Integrin β2 chain
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse CTL glycoproteins
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG2a κ
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For Research Use Only.

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