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Description
CD18 or integrin Β-2 is a transmembrane glycoprotein. It complexes non-covalently with either α L, α M, or α X integrin (CD11a, b, or c) to form the heterodimers, LFA-1, Mac-1, and p150,95, respectively. LFA-1 is the receptor for three members of the Ig supergene family of proteins, ICAM-1 (CD54), ICAM-2 (CD102), and Mac-1 and p150,95 bind to ICAM-1, fibrinogen, and iC3b. ICAM-3 (CD50). CD18/CD11 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses.
Host Species: Mouse
Clone: 68-5A5
Isotype: IgG2a
Cross Reactivity: Human. Others-not tested.
Epitope: Not determined
Immunogen: Stimulated human leukocytes.
Molecular Weight: 95kDa
Positive Control: Tonsil.
Cellular Localization: Cell membrane
Flow Cytometry, Immunofluorescence, Immunohistochemistry
Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly
Specifications
Specifications
| Antigen | CD18 Ab-1 |
| Classification | Monoclonal |
| Concentration | 1mg/mL |
| Conjugate | Unconjugated |
| Host Species | Mouse |
| Immunogen | Stimulated human leukocytes. |
| Purification Method | Tonsil |
| Quantity | 100 μL |
| Primary or Secondary | Primary |
| Target Species | Human |
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