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CD180 Rat anti-Mouse, NA/LE, Unlabeled, Clone: RP/14, BD

Catalog No. BDB562191 Shop All BD Biosciences Products
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BDB562191 0.5 mg
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Catalog No. BDB562191 Supplier BD Biosciences Supplier No. 562191
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Description

Rat Monoclonal Antibody

The RP/14 monoclonal antibody specifically binds to CD180, the “radioprotective” 105 kDa (RP105) antigen expressed on mature B lymphocytes. Like other members of the Toll-like Receptor (TLR) family, the extracellular region of CD180 contains tandem repeats of a leucine-rich motif flanked by regions containing conserved cysteines. These characteristic structural components of TLR may mediate protein-protein interactions and regulation of signal transduction involved in innate immune responses. Furthermore, CD180 associates with the secretory protein MD-1 on the cell surface. Cross-linking of cell-surface CD180 with the RP/14 antibody induces activation signals in B lymphocytes. Despite the expression of CD180 on lymphocytes of all strains tested (BALB/c, BALB/c. xid , C3H, C57BL/6, CBA/N, and 129/Sv), some strains (BALB/c. xid , C57BL/6. xid , CBA/N, 129/Sv, and 129/Ola) display deficient responses to that stimulatory effects of mAb RP/14.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD180
Applications Flow Cytometry
Classification Monoclonal
Clone RP/14
Concentration 1.0mg/mL
Conjugate Unconjugated
Description Ly78; Ly-78; Lymphocyte antigen 78; RP105; Radioprotective 105 kDa protein
Formulation No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
Host Species Rat
Immunogen BALB/c mouse splenocytes
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG2a κ
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