Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

CD180 Rat anti-Mouse, Unlabeled, Clone: RP/14, BD

Rat Monoclonal Antibody

Supplier:  BD Biosciences 552128

Catalog No. BDB552128


Only null left
Add to Cart

Description

Description

The RP/14 antibody reacts with CD180, the “radioprotective” 105 kDa (RP105) antigen expressed on mature B lymphocytes. Like other members of the Toll-like Receptor (TLR) family, the extracellular region of CD180 contains tandem repeats of a leucine-rich motif flanked by regions containing conserved cysteines. These characteristic structural components of TLR may mediate protein-protein interactions and regulation of signal transduction involved in innate immune responses. Furthermore, CD180 associates with the secretory protein MD-1 on the cell surface. Cross-linking of cell-surface CD180 with the RP/14 antibody induces activation signals in B lymphocytes. Despite the expression of CD180 on lymphocytes of all strains tested (BALB/c, BALB/c.xid, C3H, C57BL/6, CBA/N, and 129/Sv), some strains (BALB/c.xid, C57BL/6.xid, CBA/N, 129/Sv, and 129/Ola) display deficient responses to that stimulatory effects of mAb RP/14.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

CD180
Monoclonal
0.5mg/mL
Ly78; Ly-78; Lymphocyte antigen 78; RP105; Radioprotective 105 kDa protein
Rat
Affinity Purified
RUO
Primary
Store undiluted at 4°C
Flow Cytometry
RP/14
Unconjugated
Aqueous buffered solution containing ≤0.09% sodium azide.
BALB/c mouse splenocytes
0.5 mg
Immunology
Mouse
IgG2a κ
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Product Certifications
Promotions

Promotions

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.

For Research Use Only.