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CD180 Rat anti-Mouse, Unlabeled, Clone: RP/14, BD
Rat Monoclonal Antibody
Supplier: BD Biosciences 552128
Description
The RP/14 antibody reacts with CD180, the “radioprotective” 105 kDa (RP105) antigen expressed on mature B lymphocytes. Like other members of the Toll-like Receptor (TLR) family, the extracellular region of CD180 contains tandem repeats of a leucine-rich motif flanked by regions containing conserved cysteines. These characteristic structural components of TLR may mediate protein-protein interactions and regulation of signal transduction involved in innate immune responses. Furthermore, CD180 associates with the secretory protein MD-1 on the cell surface. Cross-linking of cell-surface CD180 with the RP/14 antibody induces activation signals in B lymphocytes. Despite the expression of CD180 on lymphocytes of all strains tested (BALB/c, BALB/c.xid, C3H, C57BL/6, CBA/N, and 129/Sv), some strains (BALB/c.xid, C57BL/6.xid, CBA/N, 129/Sv, and 129/Ola) display deficient responses to that stimulatory effects of mAb RP/14.

Specifications
CD180 | |
Monoclonal | |
0.5mg/mL | |
Ly78; Ly-78; Lymphocyte antigen 78; RP105; Radioprotective 105 kDa protein | |
Rat | |
Affinity Purified | |
RUO | |
Primary | |
Store undiluted at 4°C |
Flow Cytometry | |
RP/14 | |
Unconjugated | |
Aqueous buffered solution containing ≤0.09% sodium azide. | |
BALB/c mouse splenocytes | |
0.5 mg | |
Immunology | |
Mouse | |
IgG2a κ |
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