CD180 Rat anti-Mouse, Clone: RP/14, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA140034
MA1-40034 detects CD180 from mouse samples. MA1-40034 has been successfully used in flow cytometry and funtional applications. The MA1-40034 immunogen is mouse RP105/CD180. Endotoxin level < 24 EU/mg.Radioprotective 105 (RP105, CD180) is a 105 kDa type 1 transmembrane protein consisting of extracellular leucine-rich repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to Drosophila Toll in the extracellular LLRs. Radioprotective 105 (RP105, CD180) expression is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody-mediated (RP/14) cross-linking of RP105 induces resistance against irradiation-induced apoptosis, B-cell proliferation, and up-regulation of a costimulatory molecule B7.2, revealing RP105 as a potent regulator of B-cell activation. RP105 (CD180) has an important role in B-cell activation by LPS. It is important to note that RP105 associates with MD1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. MD-1 seems to be requisite for efficient expression of RP105.
|PBS with 0.1% BSA and no preservative|
|LY64, Ly78, CD180 antigen, lymphocyte antigen 64, lymphocyte antigen-64 radioprotective, radioprotective 105 kDa protein|
|Flow Cytometry, Functional Assay|
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