CD184 Rat anti-Mouse, APC, Clone: 2B11/CXCR4, BD

Rat Monoclonal Antibody

Supplier:  BD Biosciences 558644

Catalog No. BDB558644

Description

The 2B11/CXCR4 monoclonal antibody specifically reacts with mouse CD184, which is also known as CXC chemokine receptor, CXCR4. CXCR4 (previously known as Fusin and LESTR), a seven-transmembrane, G-protein-coupled receptor, is the specific receptor for CXC chemokines, SDF-1/CXCL12. Mouse CXCR4 shows 91% homology at amino acid level with human CXCR4. CXCR4 is widely expressed by hematopoietic and non-hematopoietic cell types including neutrophils, monocytes, T cells, B cells, CD34-positive progenitor cells, endothelial cells, neurons and astrocytes. In the thymus CXCR4 is restricted to CD4+CD8+ cells, while in the spleen, predominant expression is found on B lymphocytes. Human CXCR4 is used by T-tropic HIV-1 as a co-receptor for viral entry. The mouse CXCR4 gene has been mapped to chromosome 1.

Specifications

• Antigen: CD184
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: CXCR4, C-X-C chemokine receptor type 4; Fusin; LESTR; PB-CKR; Sdf1r
• Host Species: Rat
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: 2B11/CXCR4
• Conjugate: APC
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: GST-NCXCR4 fusion protein
• Quantity: 0.1 mg
• Research Discipline: Immunology
• Target Species: Mouse
• Isotype: IgG2b κ

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov