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CD19 Rat anti-Mouse, V450, Clone: 1D3, BD

Catalog No. BDB560376 Shop All BD Biosciences Products
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BDB560375 0.1 mg
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Description

Rat Monoclonal Antibody

The 1D3 antibody reacts with CD19, a B lymphocyte-lineage differentiation antigen. CD19, a 95kDa transmembrance glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymphocyte development from the pro-B cell through the mature B-cell stages. Terminally differentiated plasma cells do not express CD19. On the surface of mature B cells, the CD19 molecule associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to promote cellular activation. Studies with CD19-deficient mice have suggested that the level of CD19 expression affects the generation and maturation of B cells in the bone marrow and periphery. B-1 lineage B cells, also known as CD5+ B cells, are drastically reduced or absent in CD19-deficient mice. Increased levels of CD19 expression correlate with increased frequencies of peritonal and splenic B-1 cells and reduced numbers of conventional B lymphocytes in the periphery. CD19 participates in B-lymphocyte development, B-cell activation, maturation of memory B cells and regulation of tolerance. CD19 has also been detected on peritoneal mast cells, co-localized with CD21/CD35, and it is proposed to
play a role in complement-mediated mast-cell activation. The antibody is conjugated to BD Horizon™ V450, which has been developed for use in multicolor flow cytometry experiments and is available exclusively from BD Biosciences. It is excited by the Violet laser Ex max of 406nm and has an Em Max at 450nm. Conjugates with
BD Horizon™ V450 can be used in place of Pacific Blue™ conjugates.

Host Species: Rat
Clone: 1D3
Isotype: IgG2a κ
Species Reactivity: Mouse
Immunogen: Mouse CD19 Transfected Cell Line

Flow Cytometry, Immunohistochemistry (Frozen), Intracellular Staining

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD19
Applications Flow Cytometry
Classification Monoclonal
Clone 1D3
Concentration 0.2mg/mL
Conjugate Violet Fluor 450 (V450)
Formulation Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse CD19 Transfected Cell Line
Purification Method Affinity Purified
Quantity 25 μg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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For Research Use Only.

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