CD193 Mouse anti-Human, PE, Clone: 5E8 (also known as 5E8-G9-B4), BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 558165

Catalog No. BDB558165

Description

The 5E8 monoclonal antibody specifically binds to human CCR3 which is also known as CD193. CCR3 is a G protein-linked, 7 transmembrane, chemokine receptor expressed on a variety of hematopoietic cells. Similar to CCR5 and CXCR4, CCR3 can be a co-receptor for HIV-1. It is primarily expressed by eosinophils and basophils during atopic conditions, dermatitis, allergic rhinitis, conjunctivitis and bronchial asthma. Chemokines including RANTES, Eotaxin, MCP-3, MIP1 α have been reported to act as ligands for CCR3 and stimulate CCR3+ cells. Eotaxin stimulates Th2 cells expressing CCR3. Other studies describe HIV-1 specific T cell cytotoxicity can be mediated by RANTES and Eotaxin through CCR3. CCR3 expressed on dendritic cells may have a biological role on cell-cell interaction during antigen presentation. CCR3 has been clustered as CD193 in the HLDA VIIIth workshop.

Specifications

• Antigen: CD193
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: CCR3: Chemokine (C-C motif) receptor 3; C-C CKR-3; CKR3; CMKBR3
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG2b κ

• Applications: Flow Cytometry
• Clone: 5E8 (also known as 5E8-G9-B4)
• Conjugate: PE
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Human CCR3 Transfected Cell Line
• Quantity: 0.1 mg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

For Research Use Only.