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CD193 Mouse anti-Human, PE, Clone: 5E8 (also known as 5E8-G9-B4), BD

Catalog No. BDB558165 Shop All BD Biosciences Products
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Catalog No. BDB558165 Supplier BD Biosciences Supplier No. 558165
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Description

Mouse Monoclonal Antibody

The 5E8 monoclonal antibody specifically binds to human CCR3 which is also known as CD193. CCR3 is a G protein-linked, 7 transmembrane, chemokine receptor expressed on a variety of hematopoietic cells. Similar to CCR5 and CXCR4, CCR3 can be a co-receptor for HIV-1. It is primarily expressed by eosinophils and basophils during atopic conditions, dermatitis, allergic rhinitis, conjunctivitis and bronchial asthma. Chemokines including RANTES, Eotaxin, MCP-3, MIP1 α have been reported to act as ligands for CCR3 and stimulate CCR3+ cells. Eotaxin stimulates Th2 cells expressing CCR3. Other studies describe HIV-1 specific T cell cytotoxicity can be mediated by RANTES and Eotaxin through CCR3. CCR3 expressed on dendritic cells may have a biological role on cell-cell interaction during antigen presentation. CCR3 has been clustered as CD193 in the HLDA VIIIth workshop.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD193
Applications Flow Cytometry
Classification Monoclonal
Clone 5E8 (also known as 5E8-G9-B4)
Concentration 0.2mg/mL
Conjugate PE
Description CCR3: Chemokine (C-C motif) receptor 3; C-C CKR-3; CKR3; CMKBR3
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human CCR3 Transfected Cell Line
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2b κ
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For Research Use Only.

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