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CD193 Mouse anti-Human, PerCP-Cy5.5, Clone: 5E8 (also known as 5E8-G9-B4), BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 564189

Catalog No. BDB564189


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Description

Description

The 5E8 monoclonal antibody specifically binds to human CCR3 which is also known as CD193. CCR3 is a G protein-linked, 7 transmembrane, chemokine receptor expressed on a variety of hematopoietic cells. Similar to CCR5 and CXCR4, CCR3 can be a co-receptor for HIV-1. It is primarily expressed by eosinophils and basophils during atopic conditions, dermatitis, allergic rhinitis, conjunctivitis and bronchial asthma. Chemokines including RANTES, Eotaxin, MCP-3, MIP1 α have been reported to act as ligands for CCR3 and stimulate CCR3+ cells. Eotaxin stimulates Th2 cells expressing CCR3. Other studies describe HIV-1 specific T cell cytotoxicity can be mediated by RANTES and Eotaxin through CCR3. CCR3 expressed on dendritic cells may have a biological role on cell-cell interaction during antigen presentation. CCR3 has been clustered as CD193 in the HLDA VIIIth workshop.

Specifications

Specifications

CD193
5E8 (also known as 5E8-G9-B4)
CCR3: Chemokine (C-C motif) receptor 3; C-C CKR-3; CKR3; CMKBR3
Affinity Purified
Human CCR3 Transfected Cell Line
100 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
PerCP-Cyanine5.5
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Murine
IgG2b, κ
RUO
Primary
Human
Documents
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