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CD197 (CCR7) Mouse anti-Human, Unlabeled, Clone: 2H4, BD

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Description

Mouse Monoclonal Antibody

The monoclonal antibody 2H4 reacts with the human CC chemokine receptor, CCR7/CD197. CCR7 (previously known as BLR-2, EBI-1 and CMKBR7), a seven-transmembrane, G-protein-coupled receptor, is the specific receptor for CC chemokines, MIP-3•/Exodus 3/ELC/CCL19 and 6Ckine/Exodus 2/SLC/TCA4/CCL214. It has been shown that CCR7 mRNA is expressed mainly in lymphoid tissues including spleen, lymph nodes and tonsil. CCR7 mRNA was also detected in peripheral T- and B-lymphocytes, in BM and cord blood CD34-positive cells and mature dendritic cells. The human CCR7 gene, unlike other CC chemokine receptor genes, has been mapped to chromosome 17q12. The immunogen used to generate 2H4 hybridoma was human CCR7 transfected L1.2 mouse lymphoma cells. This antibody is not a neutralizing antibody.

This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD197
Applications Flow Cytometry
Classification Monoclonal
Clone 2H4
Concentration 0.5mg/mL
Conjugate Unconjugated
Description CCR7, BLR-2, EBI-1 and CMKBR7
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human CCR7 transfected L1.2 mouse lymphoma cells
Purification Method Affinity Purified
Quantity 0.25 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C
Isotype IgM κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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