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CD197 (CCR7) Mouse anti-Human, FITC, Clone: 150503, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 561271

Catalog No. BDB561271


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Description

Description

The monoclonal antibody 150503 specifically binds to the human CC chemokine receptor, CCR7, also known as CD197. CCR7 (previously known as BLR2, EBI1 and CMKBR7), a seven-transmembrane, G-protein-coupled receptor, is the specific receptor for CC chemokines, MIP-3β/Exodus 3/ELC/ CCL19 and 6Ckine/Exodus 2/SLC/TCA4/CCL21. CCR7 mRNA is expressed mainly in lymphoid tissues including spleen, lymph nodes and tonsil. CCR7 is expressed on peripheral T and B lymphocytes, by bone marrow and cord blood CD34-positive cells and by mature dendritic cells. Differential CCR7 expression can be used to distinguish naive, central memory and effector memory T cell subsets. The human CCR7 gene, unlike other CC chemokine receptor genes, has been mapped to chromosome 17 (region 17q12).

Under some complex multi-color conditions, this clone may non-specifically interact with antibodies conjugated with APC-H7 or APC-Cy7, contributing to staining artifacts. BD Horizon Brilliant™ Stain Buffer (Cat. No. 563794), designed to minimize on non-specific fluorescent dye interactions, does not resolve this interaction with either APC-H7 or APC-Cy7. For optimal multicolor staining results, alternatives to APC-H7 and APC-Cy7 should be evaluated.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

CD197
Monoclonal
FITC
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Human CCR7 Transfected Cell Line
100 Tests
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Flow Cytometry
150503
CC chemokine receptor 7; BLR2; CMKBR7; EBI1; EVI1; MIP-3 beta receptor
Mouse
Affinity Purified
RUO
Human
IgG2a
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