CD1d Rat anti-Mouse, Unlabeled, Clone: 3C11, BD

Rat Monoclonal Antibody

Supplier:  BD Biosciences 559871

Catalog No. BDB559871

Description

The 3C11 antibody reacts with CD1d, a 48-kDa glycoprotein with structural homology to the major histocompatibility complex (MHC) class I molecules. The structure, expression, and functions of CD1 antigens are complex and have been reviewed. mAb 3C11 detects CD1d at varying levels on most types of bone marrow and peripheral leukocytes and on epithelial, dendritic, and lymphoid cells in the thymus. It appears to recognize CD1d only in association with β2m. CD1d has been reported to be expressed by gastrointestinal tract epithelium and in the cytoplasm of hepatocytes as detected via immunohistochemical staining of frozen sections with mAb 3C11, suggesting a possible role for CD1d in mucosal immunity. However, CD1d expression was not detectable, via flow cytometry, on intestinal epithelial cells in studies using the anti-CD1d mAbs 3C11, 1B1 (Cat. no. 553843, for the purified antibody), and 9C7. The 3C11 mAb is reported to cross-react with human CD1d, and it competes with mAb 1B1 (Cat. no. 553844) in binding to mouse splenocytes.

Specifications

• Antigen: CD1d
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Description: CD1.1, Ly-38
• Host Species: Rat
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

• Applications: Flow Cytometry
• Clone: 3C11
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: L cells (derived from C3H/An mouse) expressing full-length mouse Cd1.1 cDNA
• Quantity: 0.5 mg
• Research Discipline: Immunology
• Target Species: Mouse
• Isotype: IgM κ

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov