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CD20 Mouse anti-Human, Brilliant Violet 510, Clone: H1, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 563347

Catalog No. BDB563347


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Description

Description

The H1 (FB1) antibody specificially binds to a cytoplasmic domain of CD20. CD20 is a 33-37-kDa four transmembrane phosphoprotein that is expressed by B lymphocytes from the pre-B stage and most malignant B cells and is lost during plasma cell differentiation. Low level CD20 expression is observed on a subset of normal circulating T lymphocytes, and CD20-positive T-cell lymphomas have been reported. The CD20 molecule is associated with membrane lipid raft domains, acts as a channel for calcium ions, and is involved in the regulation of B cell activation and survival. The cytoplasmic domain regions are serine and threonine rich and contain multiple phosphorylation consensus sequences.

The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon™ Brilliant Violet™ family of dyes. With an Ex Max of 405-nm and Em Max at 510-nm, BD Horizon™ BV510 can be excited by the violet laser and detected in the BD Horizon™ V500 (525/50-nm) filter set. BD Horizon™ BV510 conjugates are useful for the detection of dim markers off the violet laser.

Specifications

Specifications

CD20
H1
MS4A1; membrane-spanning 4-domains subfamily A member 1; B1; Bp35; LEU-16
Affinity Purified
Human B lymphoma cell line
50 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
Brilliant Violet 510
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Murine
IgG2a, κ
RUO
Primary
Human
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