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CD209a Rat anti-Mouse, APC, Clone: 5H10, BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 564928

Catalog No. BDB564928


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Description

Description

The 5H10 monoclonal antibody specifically binds to mouse CD209a, or CIRE, which is the most closely related homolog of human DC-SIGN. In the mouse, several homologs of human CD209 (DC-SIGN) have been described. CD209a is a 238-amino acid type-II transmembrane C-type lectin, with an extracellular carbohydrate recognition domain. It can bind to mannosylated ligands in a Ca++ dependent manner. CD209a is expressed by some conventional CD4+ and CD4-CD8- dendritic cells (DC) but not by CD8+ DC. It is also expressed on monocytes, splenic plasmacytoid pre-DC, macrophages, and resident peritoneal cells. CD209a expression is downregulated upon cellular activation. CD209a is thought to play a role in the internalization and presentation of antigens to initiate immune responses.

Specifications

Specifications

CD209a
5H10
APC
Aqueous buffered solution containing ≤0.09% sodium azide
Rat
IgG2a, κ
RUO
Primary
Murine
Flow Cytometry
0.2mg/mL
CD209; Cire; DC-SIGN; Dcsign; DC-SIGN1; CDSIGN
Affinity purified
Peptide Derived from Extracellular Region of CD209a/CIRE
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Documents
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