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CD212 Mouse anti-Human, BB515, Clone: 2.4E6., BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 565043

Catalog No. BDB565043


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Description

Description

The 2.4E6 monoclonal antibody specifically binds to CD212, which is also known as the Interleukin-12 Receptor beta-1 chain (IL12RB1/IL-12RB1/ IL-12Rβ1 ). CD212 serves as a subunit for the functional IL-12 Receptor (IL-12R β 1-IL-12R β 2) and IL-23 Receptor (IL-12R β 1-IL-23R) complexes. CD212 is expressed on T cells, B cells, or NK cells. CD212 is a type I transmembrane glycoprotein that belongs to the hemopoietin receptor superfamily. CD212 is responsible for binding to the IL-12 p40 subunit that is common to the heterodimeric IL-12 and IL-23 cytokines. IL-12 and IL-23 are immunomodulatory cytokines produced mainly by antigen-presenting cells (APC) including monocytes and dendritic cells. These cytokines have overlapping as well as distinct biological activities.

Specifications

Specifications

CD212
2.4E6.
IL-12R beta 1, IL-12 receptor β1 subunit
Affinity purified
PHA-activated Human PBMC
100 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
BB515
Aqueous buffered solution containing ≤0.09% sodium azide
Murine
IgG1, κ
RUO
Primary
Human
Documents
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