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CD218a (IL-18Rα) Mouse anti-Human, PE, Clone: H44, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 564675

Catalog No. BDB564675


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Description

Description

The H44 monoclonal antibody specifically binds to CD218a, which is also known as Interleukin-18 receptor 1 (IL-18R1), IL-18 Receptor alpha (IL-18R α ) and IL1 Receptor-related protein (IL-1Rrp). CD218a is a type I transmembrane glycoprotein that associates with CD218b (IL-18R β ) subunit to form the functional IL-18 Receptor Complex. Both subunits belong to the IL-1R family. The IL-18R α chain is responsible for extracellular IL-18 binding whereas the IL-18R β subunit is involved in intracellular signaling through the NF κ B pathway. CD218a is expressed on a variety of cells including T cells, NK cells, macrophages, granulocytes, keratinocytes, endothelial cells, and smooth muscle cells. CD218a expression is induced weakly in T cells by IL-12 treatment and moderately by phytohemagglutinin (PHA) stimulation. Costimulation with both IL-12 and PHA induces optimal CD218a expression on CD4+ T cells, CD8+ T cells, and CD56+ NK cells. The IL-18/IL-18R Complex plays important roles in adaptive immunity as well as innate immune responses and autoimmunity. H44 reportedly neutralized the biological activity of recombinant human IL-18 protein.

Specifications

Specifications

CD218a (IL-18Rα)
H44
IL-1Rrp; IL1RRP; IL18RA; IL-18Rα; IL-18R1; IL-18R-1; IL18R1
Affinity Purified
Human NK Cell Line
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
RUO
Primary
Human
Flow Cytometry
PE
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Murine
IgG1, κ
50 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
SDS
Documents
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