CD218a (IL-18Rα) Mouse anti-Human, PE, Clone: H44, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 564675

Catalog No. BDB564675

Description

The H44 monoclonal antibody specifically binds to CD218a, which is also known as Interleukin-18 receptor 1 (IL-18R1), IL-18 Receptor alpha (IL-18R α ) and IL1 Receptor-related protein (IL-1Rrp). CD218a is a type I transmembrane glycoprotein that associates with CD218b (IL-18R β ) subunit to form the functional IL-18 Receptor Complex. Both subunits belong to the IL-1R family. The IL-18R α chain is responsible for extracellular IL-18 binding whereas the IL-18R β subunit is involved in intracellular signaling through the NF κ B pathway. CD218a is expressed on a variety of cells including T cells, NK cells, macrophages, granulocytes, keratinocytes, endothelial cells, and smooth muscle cells. CD218a expression is induced weakly in T cells by IL-12 treatment and moderately by phytohemagglutinin (PHA) stimulation. Costimulation with both IL-12 and PHA induces optimal CD218a expression on CD4+ T cells, CD8+ T cells, and CD56+ NK cells. The IL-18/IL-18R Complex plays important roles in adaptive immunity as well as innate immune responses and autoimmunity. H44 reportedly neutralized the biological activity of recombinant human IL-18 protein.

Specifications

• Antigen: CD218a (IL-18Rα)
• Classification: Monoclonal
• Conjugate: PE
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Immunogen: Human NK Cell Line
• Quantity: 50 Tests
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: H44
• Description: IL-1Rrp; IL1RRP; IL18RA; IL-18Rα; IL-18R1; IL-18R-1; IL18R1
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG1 κ

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov