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CD22.2 Mouse anti-Mouse, Biotin, Clone: CY34.1, BD

Catalog No. BDB553382 Shop All BD Biosciences Products
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Catalog No. BDB553382 Supplier BD Biosciences Supplier No. 553382
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Description

Mouse Monoclonal Antibody

The Cy34.1 antibody reacts with the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicularand marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellulardomain is phosphorylated after cross-linking of antigen receptoror MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig µ chain are augmented in the presence of Cy34.1 mAb.

This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in literature.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD22.2
Applications Flow Cytometry
Classification Monoclonal
Clone CY34.1
Concentration 0.5mg/mL
Conjugate Biotin
Description Lyb-8.2
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen B10.D2 mouse splenocytes
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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For Research Use Only.

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