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CD221 (pY1131) Mouse, Alexa Fluor 647, Clone: K74-218, BD

Catalog No. BDB558588 Shop All BD Biosciences Products
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Catalog No. BDB558588 Supplier BD Biosciences Supplier No. 558588
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Description

Mouse Monoclonal Antibody

Insulin-like growth factor-1 (IGF-1) receptor, or CD221, is a receptor tyrosine kinase that has high affinity for IGF-1 and low affinity for insulin and IGF-2. Each transmembrane protein complex is formed from a pair of 1367 amino-acid precursor proteins. After the 30 amino-acid signal sequences are removed, the paired polypeptides are cleaved to derive an a and b chain from each. The two extracellular a chains form the ligand-binding domain, while the transmembrane-and-intracellular b chains carry the kinase activity. Upon stimulation by its ligand, IGF-1 receptor autophosphorylates multiple tyrosine sites in its b chains and phosphorylates other signaling mediators that regulate cell growth, development, and neoplastic transformation.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD221 (pY1131)
Applications Flow Cytometry
Classification Monoclonal
Clone K74-218
Conjugate Alexa Fluor 647
Description IGF1R; IGF-I receptor; IGFIR; IGFR; Insulin-like growth factor 1 receptor
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Phosphorylated Human IGF-1 Receptor Peptide
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse, Rat
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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