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Description
The MEM-238 monoclonal antibody specifically binds to CD222, which is also known as the Insulin-like growth factor 2 Receptor (IGF2R, IGF-II Receptor), Cation-independent mannose 6-phosphate receptor (CIMPR), or Mannose-6 phosphate receptor (M6PR). CD222 is ubiquitously expressed by a variety of cell types as a cell surface type I transmembrane glycoprotein. However, in the course of receptor trafficking between the cell surface and intracellular compartments, the majority of CD222 is found within cells. Cell surface CD222 functions as a multifunctional receptor that binds to a large number of extracellular ligands including acid hydrolases, insulin-like growth factors, latent TGF- β, leukemia inhibitory factor (LIF), proliferin, prorenin, plasminogen, and Herpes simplex vir us. It regulates extracellular Insulin-like growth factor II (IGF-II/IGF-2) levels by binding and internalizing the growth factor for lysosomal degradation. This effectively removes IGF-II from the circulation and tissues and thus prevents it from signaling through the growth-stimulatory Insulin-like growth factor I Receptor (IGF-1R, CD221) pathway. However, studies have reported that IGF-II may activate some cellular functions through CD222 as well. A soluble form of the CD222 extracellular region can also be detected in human serum and may play a role in regulating IGF-II activity. CD222 serves as a surface receptor for latent TGFβ and can complex with plasminogen and CD87, a urokinase-type plasminogen activator receptor, to activate latent TGF- β. CD222 also binds to a variety of Mannose 6-phosphate (M6P)-containing proteins, including extracellular and newly-synthesized lysosomal enzymes, and transports them to lysosomes.
Specifications
Specifications
| Antigen | CD222 |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Clone | MEM-238 |
| Concentration | 0.2mg/mL |
| Conjugate | Alexa Fluor 647 |
| Description | IGF2R; IGF-IIR; IGF-II Receptor; CIMPR; M6PR; MPR1; MPRI; M6P-R |
| Formulation | Aqueous buffered solution containing ≤0.09% sodium azide |
| Host Species | Mouse |
| Immunogen | Human Recombinant Vaccinia virus encoding CD222 |
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