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CD226 Mouse anti-Human, Unlabeled, Clone: DX11, BD

Catalog No. BDB559787 Shop All BD Biosciences Products
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BDB559787 0.1 mg
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Catalog No. BDB559787 Supplier BD Biosciences Supplier No. 559787
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Description

Mouse Monoclonal Antibody

Reacts with DNAX accessory molecule-1 (DNAM-1), a 65kDa transmembrane glycoprotein consisting of 318 amino acid residues including two Ig-like domains. DNAM-1 is expressed on the majority of T cells, NK cells, monocytes, and a subset of B cells, but not on granulocytes or erythrocytes. It is also present on a subset of thymocytes coexpressing high density surface CD3. DNAM-1 is not present on normal fibroblast cell lines or tumor cell lines of epithelial or neuronal origins. DNAM-1 is a tyrosinephosphorylated, signal-transducing molecule which participates in primary adhesion during cytotoxic T lymphocyte (CTL)-mediated cytotoxicity. DX11 inhibits T- and NKcell-mediated cytotoxicity against a variety of tumor cell targets, and blocks cytokine production by alloantigen-specific T cells.

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD226
Applications Flow Cytometry
Classification Monoclonal
Clone DX11
Concentration 0.5mg/mL
Conjugate Unconjugated
Description DNAM-1; DNAM1; PTA1; PTA-1; TLiSA1
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human CTL Clone
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C
Isotype IgG1 κ
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