CD226 Mouse anti-Human, NA/LE, Unlabeled, Clone: DX11, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 559786

Catalog No. BDB559786

Description

Reacts with DNAX accessory molecule-1 (DNAM-1), a 65kDa transmembrane glycoprotein consisting of 318 amino acid residues including two Ig-like domains. DNAM-1 is expressed on the majority of T cells, NK cells, monocytes, and a subset of B cells, but not on granulocytes or erythrocytes. It is also present on a subset of thymocytes coexpressing high density surface CD3. DNAM-1 is not present on normal fibroblast cell lines or tumor cell lines of epithelial or neuronal origins. DNAM-1 is a tyrosinephosphorylated, signal-transducing molecule which participates in primary adhesion during cytotoxic T lymphocyte (CTL)-mediated cytotoxicity. DX11 inhibits T- and NKcell-mediated cytotoxicity against a variety of tumor cell targets, and blocks cytokine production by alloantigen-specific T cells.

Flow Cytometry

Specifications

• Antigen: CD226
• Classification: Monoclonal
• Concentration: 1.0mg/mL
• Description: DNAM-1; DNAM1; PTA1; PTA-1; TLiSA1
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

• Applications: Flow Cytometry
• Clone: DX11
• Conjugate: Unconjugated
• Formulation: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
• Immunogen: Human CTL Clone
• Quantity: 0.5 mg
• Research Discipline: Immunology
• Target Species: Human
• Isotype: IgG1 κ