OX40 Ligand Mouse anti-Human, Brilliant Violet 421, Clone: ik-1, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 563766

Catalog No. BDB563766

Description

The ik-1 monoclonal antibody specifically binds to OX40 Ligand (OX40L) which is also known as CD252 and CD134 Ligand. OX40L is encoded by TNFSF4 (Tumor necrosis factor (ligand) superfamily, member 4). OX40L a 34 kDa type II transmembrane glycoprotein that is expressed by dendritic cells, B cells, human umbilical vein endothelial cells (HUVEC) and other types of vascular endothelial cells. OX40L serves as a costimulatory ligand by binding to and signaling through OX40 (CD134) which is expressed on activated T cells. It also mediates adhesion of activated T cells or OX40-positive transformed cells to vascular endothelial cells. Monocyte-derived dendritic cells (MoDC) express OX40 Ligand after stimulation through CD40. Ligation of OX40 Ligand expressed by activated MoDC can significantly increase their cytokine production.

Specifications

• Antigen: OX40 Ligand
• Clone: ik-1
• Description: CD252; OX40 Ligand; CD134 Ligand; CD134L; TNFSF4; GP34; TXGP1
• Format: Affinity Purified
• Immunogen: Human OX40 Ligand Transfected Cell Line
• Quantity: 50 Tests
• Storage Requirements: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Monoclonal or Polyclonal: Monoclonal

• Applications: Flow Cytometry
• Conjugate: Brilliant Violet 421
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Host Species: Murine
• Isotype: IgG₁, κ
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human