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OX40 Ligand Mouse anti-Human, Brilliant Violet 421, Clone: ik-1, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 563766

Catalog No. BDB563766


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Description

Description

The ik-1 monoclonal antibody specifically binds to OX40 Ligand (OX40L) which is also known as CD252 and CD134 Ligand. OX40L is encoded by TNFSF4 (Tumor necrosis factor (ligand) superfamily, member 4). OX40L a 34 kDa type II transmembrane glycoprotein that is expressed by dendritic cells, B cells, human umbilical vein endothelial cells (HUVEC) and other types of vascular endothelial cells. OX40L serves as a costimulatory ligand by binding to and signaling through OX40 (CD134) which is expressed on activated T cells. It also mediates adhesion of activated T cells or OX40-positive transformed cells to vascular endothelial cells. Monocyte-derived dendritic cells (MoDC) express OX40 Ligand after stimulation through CD40. Ligation of OX40 Ligand expressed by activated MoDC can significantly increase their cytokine production.

Specifications

Specifications

OX40 Ligand
ik-1
CD252; OX40 Ligand; CD134 Ligand; CD134L; TNFSF4; GP34; TXGP1
Affinity Purified
Human OX40 Ligand Transfected Cell Line
50 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
Brilliant Violet 421
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Murine
IgG1, κ
RUO
Primary
Human
Documents
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