CD258 (LIGHT) Mouse anti-Human, Alexa Fluor 647, Clone: 115520, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 564374

Catalog No. BDB564374

Description

The 115520 monoclonal antibody specifically binds to CD258 which is also known as LIGHT (is homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes). CD258 is also referred to as HVEM-L (Herpes virus entry mediator ligand), and LT- γ. This type II transmembrane glycoprotein belongs to TNF superfamily; it is encoded by TNFSF14 (tumor necrosis factor ligand superfamily member 14). CD258 is expressed by activated T cells and cultured dendritic cells. CD258 can costimulate T cells and antigen presenting cells as well as trigger apoptosis by some cell types. CD258 binds to CD270/LIGHT-R/HVEM and to the Lymphotoxin β Receptor (LT β R). LIGHT reportedly also binds to the decoy receptor (DcR3/TR6).

Specifications

• Antigen: CD258 (LIGHT)
• Clone: 115520
• Description: TNFSF14; LIGHT; HVEML; LTg
• Format: Affinity Purified
• Immunogen: Human LIGHT Recombinant Protein
• Purification Method: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human

• Applications: Flow Cytometry
• Conjugate: Alexa Fluor 647
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Host Species: Murine
• Isotype: IgG₁, κ
• Quantity: 50 Tests
• Storage Requirements: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Monoclonal or Polyclonal: Monoclonal