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CD258 (LIGHT) Mouse anti-Human, Alexa Fluor 647, Clone: 115520, BD

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BDB564374 50 Tests
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Catalog No. BDB564374 Supplier BD Biosciences Supplier No. 564374
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Description

Mouse Monoclonal Antibody

The 115520 monoclonal antibody specifically binds to CD258 which is also known as LIGHT (is homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes). CD258 is also referred to as HVEM-L (Herpes virus entry mediator ligand), and LT- γ. This type II transmembrane glycoprotein belongs to TNF superfamily; it is encoded by TNFSF14 (tumor necrosis factor ligand superfamily member 14). CD258 is expressed by activated T cells and cultured dendritic cells. CD258 can costimulate T cells and antigen presenting cells as well as trigger apoptosis by some cell types. CD258 binds to CD270/LIGHT-R/HVEM and to the Lymphotoxin β Receptor (LT β R). LIGHT reportedly also binds to the decoy receptor (DcR3/TR6).

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD258 (LIGHT)
Applications Flow Cytometry
Classification Monoclonal
Clone 115520
Conjugate Alexa Fluor 647
Description TNFSF14; LIGHT; HVEML; LTg
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human LIGHT Recombinant Protein
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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