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CD258 (LIGHT) Mouse anti-Human, Alexa Fluor 647, Clone: 115520, BD
Mouse Monoclonal Antibody
Supplier: BD Biosciences 564374
Description
The 115520 monoclonal antibody specifically binds to CD258 which is also known as LIGHT (is homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes). CD258 is also referred to as HVEM-L (Herpes virus entry mediator ligand), and LT- γ. This type II transmembrane glycoprotein belongs to TNF superfamily; it is encoded by TNFSF14 (tumor necrosis factor ligand superfamily member 14). CD258 is expressed by activated T cells and cultured dendritic cells. CD258 can costimulate T cells and antigen presenting cells as well as trigger apoptosis by some cell types. CD258 binds to CD270/LIGHT-R/HVEM and to the Lymphotoxin β Receptor (LT β R). LIGHT reportedly also binds to the decoy receptor (DcR3/TR6).

Specifications
CD258 (LIGHT) | |
Monoclonal | |
Alexa Fluor 647 | |
Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
Human LIGHT Recombinant Protein | |
50 Tests | |
Primary | |
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
Flow Cytometry | |
115520 | |
TNFSF14; LIGHT; HVEML; LTg | |
Mouse | |
Affinity Purified | |
RUO | |
Human | |
IgG1 κ |
Safety and Handling
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