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CD26 Rat anti-Mouse, FITC, Clone: H194-112, BD

Rat Monoclonal Antibody

Supplier:  BD Biosciences 559652

Catalog No. BDB559652


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Description

Description

The H194-112 monoclonal antibody specifically binds to CD26, which is also known as, Thymocyte-activating molecule (THAM), or dipeptidyl peptidase IV (DPP IV, Dpp4). CD26 is a ∽220- kDa dimer formed of identical type-II transmembrane core polypeptides which undergo variable post-translational modifications. It is a multi-functional molecule with both ectopeptidase and signal-transducing activities. Studies with specific DPP IV inhibitors suggest that the enzymatic activity is involved in the mediation of T-cell activation events. The expression of CD26 is developmentally regulated in the thymus. Resting lymphoid cells of the bone marrow and peripheral B and T lymphocytes express low levels of CD26; bone-marrow and peritoneal myeloid cells do not. CD26 is also found on epithelial cells in the kidney, liver, small intestine, and lung. Cross-linked H194-112 mAb induces proliferation of immature and mature thymocytes in the presence of either IL-1 plus IL-2 or PMA; addition of IL-2 or IL-4 to PMA further enhances the activation.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

CD26
Monoclonal
0.5mg/mL
Cd26; Dpp4; dipeptidylpeptidase 4; THAM, DPP IV
Rat
Affinity Purified
RUO
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Flow Cytometry
H194-112
FITC
Aqueous buffered solution containing ≤0.09% sodium azide.
Cell-surface molecules solubilized from BALB/c mouse thymocytes
0.1 mg
Immunology
Mouse
IgG2a κ
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