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CD270 (HVEM) Rat anti-Mouse, Alexa Fluor 647, Clone: C46, BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 564470

Catalog No. BDB564470


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Description

Description

The C46 monoclonal antibody specifically binds to HVEM (Herpes virus entry mediator) which is also known as CD270. CD270 is a type I transmembrane protein and member of the TNF Receptor superfamily. It is encoded by Tnfrsf14 (tumor necrosis factor receptor superfamily member 14). CD270 is expressed by a variety of cell types including T cells, B cells, monocytes, dendritic cells, neutrophils, and mucosal epithelial cells. CD270 is a multifunctional factor that can both augment or inhibit immune responses. CD270 binds several ligands including CD258/LIGHT (is homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), CD160, and CD272/BTLA. CD270-LIGHT interactions reportedly transduce costimulatory signals for T cells whereas CD270 interaction with BTLA can induce coinhibitory signals that regulate T cell-dependent immune responses.

Specifications

Specifications

CD270 (HVEM)
C46
Alexa Fluor 647
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Rat
IgG1, κ
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
0.2mg/mL
HVEM; Herpes virus entry mediator; Tnfrsf14; HveA; Atar
Affinity Purified
Mouse HVEM Transfected Cell Line
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
RUO
Primary
Murine
Documents
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