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CD270 (HVEM) Rat anti-Mouse, Alexa Fluor 647, Clone: C46, BD

Catalog No. BDB564470 Shop All BD Biosciences Products
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BDB564470 50 μg
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Catalog No. BDB564470 Supplier BD Biosciences Supplier No. 564470

Description

Rat Monoclonal Antibody

The C46 monoclonal antibody specifically binds to HVEM (Herpes virus entry mediator) which is also known as CD270. CD270 is a type I transmembrane protein and member of the TNF Receptor superfamily. It is encoded by Tnfrsf14 (tumor necrosis factor receptor superfamily member 14). CD270 is expressed by a variety of cell types including T cells, B cells, monocytes, dendritic cells, neutrophils, and mucosal epithelial cells. CD270 is a multifunctional factor that can both augment or inhibit immune responses. CD270 binds several ligands including CD258/LIGHT (is homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), CD160, and CD272/BTLA. CD270-LIGHT interactions reportedly transduce costimulatory signals for T cells whereas CD270 interaction with BTLA can induce coinhibitory signals that regulate T cell-dependent immune responses.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD270 (HVEM)
Applications Flow Cytometry
Classification Monoclonal
Clone C46
Concentration 0.2mg/mL
Conjugate Alexa Fluor 647
Description HVEM; Herpes virus entry mediator; Tnfrsf14; HveA; Atar
Formulation Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse HVEM Transfected Cell Line
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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