CD270 (HVEM) Rat anti-Mouse, Alexa Fluor 647, Clone: C46, BD

Rat Monoclonal Antibody

Supplier:  BD Biosciences 564470

Catalog No. BDB564470

Description

The C46 monoclonal antibody specifically binds to HVEM (Herpes virus entry mediator) which is also known as CD270. CD270 is a type I transmembrane protein and member of the TNF Receptor superfamily. It is encoded by Tnfrsf14 (tumor necrosis factor receptor superfamily member 14). CD270 is expressed by a variety of cell types including T cells, B cells, monocytes, dendritic cells, neutrophils, and mucosal epithelial cells. CD270 is a multifunctional factor that can both augment or inhibit immune responses. CD270 binds several ligands including CD258/LIGHT (is homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), CD160, and CD272/BTLA. CD270-LIGHT interactions reportedly transduce costimulatory signals for T cells whereas CD270 interaction with BTLA can induce coinhibitory signals that regulate T cell-dependent immune responses.

Specifications

• Antigen: CD270 (HVEM)
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: HVEM; Herpes virus entry mediator; Tnfrsf14; HveA; Atar
• Host Species: Rat
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Mouse
• Isotype: IgG1 κ

• Applications: Flow Cytometry
• Clone: C46
• Conjugate: Alexa Fluor 647
• Formulation: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
• Immunogen: Mouse HVEM Transfected Cell Line
• Quantity: 50 μg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.