CD271 Mouse anti-Human, Brilliant Violet 421, Clone: C40-1457, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 562562

Catalog No. BDB562562

Description

The C40-1457 monoclonal antibody specifically binds to CD271, the nerve growth factor receptor (NGFR). CD271 is a transmembrane 75 kDa protein that has been found localized to neuronal axons, Schwann cells, and perineural cells of peripheral nerves. It is also expressed by cells in some epithelial, mesenchymal and lymphoid tissues. NGFR is the receptor for nerve growth factor (NGF), a polypeptide that is essential for normal development of the nervous system. NGF promotes survival and differentiation of sympathetic and sensory neurons during embryological development of peripheral neurons. NGF binds to two distinctive surface receptors expressed by target cells, the p140-TrkA (NTRK1) and the p75 NGFR. High affinity binding of NGF requires that both receptor molecules be expressed. NGFR has been found on human and rat lymphocytes. A subset of lymphoid cells in the spleen, lymph nodes, and follicular dentritic cells in germinal centers of reactive lymph nodes were found to express CD271. It has been reported that NGFR interaction with its ligand, NGF, may play a role in immunoregulation. NGF may function as a B-cell growth factor.

The antibody was conjugated to BD Horizon™ BV421 which is part of the BD Horizon™ Brilliant Violet™ family of dyes. With an Ex Max of 407-nm and Em Max at 421-nm, BD Horizon™ BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50-nm filter). BD Horizon™ BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue™ conjugates.

Specifications

• Antigen: CD271
• Classification: Monoclonal
• Conjugate: Brilliant Violet 421
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG1 κ

• Applications: Flow Cytometry
• Clone: C40-1457
• Description: NGFR; NTR; p75NTR; p75 ICD; TNFRSF16; TNR16; LNGFR
• Host Species: Mouse
• Quantity: 50 Tests
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov