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CD272 (BTLA) Mouse anti-Human, APC, Clone:  J168-540, BD

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BDB564800 50 μg
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Catalog No. BDB564800 Supplier BD Biosciences Supplier No. 564800
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Description

Mouse Monoclonal Antibody

The J168-540 monoclonal antibody specifically binds to human CD272, also known as BTLA (B and T lymphocyte attenuator), an inhibitory receptor expressed in bone marrow and thymus on developing B and T cells. In the periphery, BTLA is expressed by B cells, T cells, bone marrow-derived dendritic cells, and macrophages. After T cell activation, BTLA appears to be expressed at higher levels on Th1 cell populations than in Th2 cell populations. Upon binding the herpesvirus entry mediator (HVEM/LIGHT-R/CD270), CD272 undergoes tyrosine phosphorylation and inhibits T cell proliferation in a BTLA-dependent manner. CD272 has structural similarities to two other lymphocyte inhibitory receptors, CTLA-4 and PD-1 and is a member of the CD28-like family of coreceptors. Based on these observations, CD272 is considered to be a negative regulator of lymphocyte activation and/or function.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD272 (BTLA)
Applications Flow Cytometry
Classification Monoclonal
Clone  J168-540
Concentration 0.2mg/mL
Conjugate APC
Description BTLA1; B- and T-lymphocyte-associated protein
Formulation Aqueous buffered solution containing ≤0.09% sodium azide
Host Species Mouse
Immunogen Human BTLA Recombinant Protein
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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