CD272 Hamster anti-Mouse, PE, Clone: HMBT-6B2, BD
Hamster Monoclonal Antibody
Manufacturer: BD Biosciences 563774
The HMBT-6B2 monoclonal antibody specifically binds to CD272 which is also known as B- and T-lymphocyte attenuator (BTLA). CD272 is a type 1 transmembrane glycoprotein and a member of the Ig superfamily. CD272 is variably expressed on developing and mature T and B lymphocytes, NKT cells, NK cells, macrophages and dendritic cells. CD272 expression is upregulated by activated T cells including Th1, Th2, and T follicular helper cells and by anergic T cells. CD272 is structurally similar to CD152/CTLA-4 and CD279/PD-1 and functions as a coinhibitory receptor for B and T cell responses. Herpesvirus entry mediator (HVEM), also known as CD270 and LIGHT-R, has been identified as a ligand for CD272. The crosslinking of CD272 by HVEM inhibits T-cell proliferation and cytokine production.
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Btla; B and T lymphocyte attenuator; B- and T-lymphocyte-associated protein|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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