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CD274 Mouse anti-Human, PE-CF594, Clone: MIH1, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 563742

Catalog No. BDB563742

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The MIH1 monoclonal antibody specifically binds to CD274, also known as Programmed Death Ligand 1 (PD-L1) and B7 Homolog 1 (B7-H1). CD274/PD-L1 and CD273/PD-L2 are members of the B7 family within the Immunoglobulin superfamily. These type I transmembrane glycoproteins function as ligands for CD279, likewise known as the Programmed Death 1 (PD-1) receptor. CD274 is expressed on activated dendritic cells, macrophages and T cells. Studies show some overlapping functions of CD274 and CD273 and indicate an important role for CD279 and its ligands in regulating T and B cell responses. CD274 is also expressed on placental trophoblasts, myocardial endothelium, cortical thymic epithelial cells, keratinocytes, and carcinomas. The MIH1 antibody is reportedly a blocking antibody.

This antibody is conjugated to BD Horizon™ PE-CF594, which has been developed exclusively by BD Biosciences as a better alternative to PE-Texas Red™. PE-CF594 excites and emits at similar wavelengths to PE-Texas Red™ yet exhibits improved brightness and spectral characteristics. Due to PE having maximal absorption peaks at 496nm and 564nm, PE-CF594 can be excited by the blue (488-nm), green (532-nm) and yellow-green (561-nm) lasers and can be detected with the same filter set as PE-Texas Red™ (eg 610/20-nm filter).



B7-H1; Programmed death ligand 1; PD-L1; PDCD1 ligand 1; PDCD1L1; PDCD1LG1
Affinity Purified
Human B7-H1 Transfected Cell Line
100 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Flow Cytometry
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
IgG1, κ
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