CD278 Mouse anti-Human, Unlabeled, Clone: DX29, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 557801

Catalog No. BDB557801

Description

The DX29 monoclonal antibody specifically binds to human CD278 which is also known as inducible costimulator (ICOS) and inducible T-cell co-stimulator. ICOS is a homodimeric type I transmembrane glycoprotein with an approximate molecular weight of 50-60 kDa. It is a member of the CD28 family and is highly expressed on activated T cells. CD278 is the receptor for ICOS-ligand (also known as CD275, B7-H2, B7RP-1, and LICOS). Like CD28, ICOS can provide a costimulatory signal for T cell activation, proliferation and cytokine production. It is not expressed on resting or activated B cells, monocytes, NK cells, granulocytes, dendritic cells or platelets. Unlike the constitutively expressed CD28, ICOS is de novo expressed upon cellular activation. Reports describe similarities between CD28 and ICOS in T cell activation, such as the costimulation of cytokine production. However, it has been suggested that ICOS may play a greater role in IL-10 production. In the presence of IL-10, purified recombinant human ICOS protein significantly increased in vitro B cell growth stimulated by pokeweed mitogen (PWM) and enhanced production of IgG.

Specifications

• Antigen: CD278
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Description: ICOS; DX-29; H4; Inducible T-cell costimulator; AILIM; CVID1
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

• Applications: Flow Cytometry
• Clone: DX29
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Activated human T cells
• Quantity: 0.1 mg
• Research Discipline: Immunology
• Target Species: Human
• Isotype: IgG1 κ

For Research Use Only.