CD278 Mouse anti-Human, PE, Clone: DX29, BD

Catalog No.	Quantity
BDB557802	100 Tests

Catalog No. BDB557802 Supplier BD Biosciences Supplier No. 557802

Description

Mouse Monoclonal Antibody

The DX29 monoclonal antibody specifically binds to human CD278 which is also known as inducible costimulator (ICOS) and inducible T-cell co-stimulator. ICOS is a homodimeric type I transmembrane glycoprotein with an approximate molecular weight of 50-60 kDa. It is a member of the CD28 family and is highly expressed on activated T cells. CD278 is the receptor for ICOS-ligand (also known as CD275, B7-H2, B7RP-1, and LICOS). Like CD28, ICOS can provide a costimulatory signal for T cell activation, proliferation and cytokine production. It is not expressed on resting or activated B cells, monocytes, NK cells, granulocytes, dendritic cells or platelets. Unlike the constitutively expressed CD28, ICOS is de novo expressed upon cellular activation. Reports describe similarities between CD28 and ICOS in T cell activation, such as the costimulation of cytokine production. However, it has been suggested that ICOS may play a greater role in IL-10 production. In the presence of IL-10, purified recombinant human ICOS protein significantly increased in vitro B cell growth stimulated by pokeweed mitogen (PWM) and enhanced production of IgG.

Specifications

• Antigen: CD278
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: DX29
• Conjugate: PE
• Description: ICOS; DX-29; H4; Inducible T-cell costimulator; AILIM; CVID1
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Activated human T cells
• Purification Method: Affinity Purified
• Quantity: 100 Tests
• Regulatory Status: RUO
• Research Discipline: Immunology
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Isotype: IgG1 κ

For Research Use Only.