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CD278 Rat anti-Mouse, PE, Clone: 7E.17G9, BD

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BDB552146 0.2 mg
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Catalog No. BDB552146 Supplier BD Biosciences Supplier No. 552146
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Description

Rat Monoclonal Antibody

The 7E.17G9 antibody reacts with CD278, the Inducible Costimulatory molecule (ICOS), a 47-57 kDa homodimeric glycoprotein of the CD28 family of costimulatory molecules. ICOS is expressed on subpopulations of CD4-CD8- and CD4+CD8- (but not CD4-CD8+ or CD4+CD8+) thymocytes, on some T-cell lines, and on small numbers of peripheral leukocytes. It is upregulated on T lymphocytes following activation via the T-cell receptor. The T-cell activation marker H4 is the same molecule asICOS. ICOS is a costimulatory receptor, and its ligand on antigen-presenting cells has been called B7RP-1, GL50, B7h, B7-H2, or LICOS. There is considerable evidence that the interaction of ICOS with its ligand is involved in the regulation of many, but not all, T-cell-mediated immune responses.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD278
Applications Flow Cytometry
Classification Monoclonal
Clone 7E.17G9
Concentration 0.2mg/mL
Conjugate PE
Description ICOS; Ailim; CCLP; CRP-1; Ly115; Inducible T-cell costimulator
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse Icos cDNA and ICOS hexahistidine fusion protein
Purification Method Affinity Purified
Quantity 0.2 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2b κ
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For Research Use Only.

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