CD28 Hamster anti-Mouse, Biotin, Clone: 37.51, BD

Catalog No.	Quantity
BDB553296	0.5 mg

Catalog No. BDB553296 Supplier BD Biosciences Supplier No. 553296

Description

Hamster Monoclonal Antibody

The 37.51 antibody reacts with CD28, which is expressed on most thymocytes, at low density on nearly all CD4+ and CD8+ peripheral T cells, and at even lower density on NK cells. The expression of CD28, in splenocytes and thymocytes,has been reported to increase after activation. CD28 transcripts are found in mast cells, and cell-surface expression of CD28 is induced upon maturation or activation of mast cells. It has been reported that CD28 is not expressed on some populations of intraepithelial T lymphocytes. CD28 is a costimulatory receptor; its ligands include CD80 (B7-1) and CD86 (B7-2). The 37.51 mAb augments proliferation and cytokine production by activated T and NK cells and can provide a costimulatory signal for CTL induction. There is considerable evidence that CD28 is a costimulatory receptor involved in many, but not all, T cell-dependent immune responses.

This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Specifications

• Antigen: CD28
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: 37.51
• Concentration: 0.5mg/mL
• Conjugate: Biotin
• Formulation: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
• Host Species: Hamster
• Immunogen: Mouse EL-4 (T-cell lymphoma) Cells
• Purification Method: Affinity Purified
• Quantity: 0.5 mg
• Regulatory Status: RUO
• Research Discipline: Immunology
• Primary or Secondary: Primary
• Target Species: Mouse
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Isotype: IgG2 λ1

For Research Use Only.