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CD28 Mouse anti-Rat, FITC, Clone: JJ319, BD

Catalog No. BDB550973 Shop All BD Biosciences Products
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BDB550973 0.1 mg
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Catalog No. BDB550973 Supplier BD Biosciences Supplier No. 550973

Description

Mouse Monoclonal Antibody

The JJ319 antibody reacts with CD28, which is expressed on virtually all T lymphocytes bearing αβ T-cell receptors (TCR), on most γδ TCR-bearing T cells, and on a subset of NK cells. In the thymus, CD28 expression is developmentally regulated during the maturation of αβ TCR-bearing T cells. CD28 is a costimulatory receptor required for activation of T cells; its ligands include CD80 (B7-1) and CD86 (B7-2). Soluble JJ319 mAb costimulates the proliferative responses and IL-2 production of CD4+ and CD8+ T cells activated by anti-αβ-TCR mAb R73 (Cat. no. 554910). The alternate anti-rat CD28 mAb JJ316 (Cat. No. 554992) is capable of directly stimulating T cells in vitro and in vivo.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD28
Applications Flow Cytometry
Classification Monoclonal
Clone JJ319
Concentration 0.5mg/mL
Conjugate FITC
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Rat CD28-transfected cell line
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Rat
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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For Research Use Only.

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