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CD284 Rat anti-Mouse, NA/LE, Unlabeled, Clone: MTS510, BD

Catalog No. BDB562221 Shop All BD Biosciences Products
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BDB562221 0.5 mg
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Catalog No. BDB562221 Supplier BD Biosciences Supplier No. 562221

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Description

Rat Monoclonal Antibody

The MTS510 antibody reacts with the molecular complex of Toll-Like Receptor 4 and MD-2 (TLR4-MD-2) which is expressed on LPS responsive macrophages. TLR4, a member of the Toll-Like Receptor Family, has been renamed CD284 and identified to be the transmembrane signal-transducing portion of the receptor for LPS. TLR4 associates on the cell surface with CD14 and MD-2, a 0.7 kDa molecule which is anchored to the membrane via its physical association with TLR4. The association of MD-2 with TLR4 is required for recognition of LPS and the anti-mitotic compound Taxol, which mimics the action of LPS on mouse cells. MTS510 mAb detects TLR4-MD-2 on the surface of thioglycollate-elicited macrophages from all mouse strains tested (ie, BALB/c, C57BL/6, C3H/HeJ, C3H/HeN, and DBA/1), including the C3H/HeJ strain which expresses an LPS-resistant mutant TLR4. Expression of TLR4-MD-2 is down-regulated on peritoneal macrophages after exposure to LPS, correlating with the occurrence of LPS tolerance. TLR4-MD-2 is not detected on splenocytes or thymocytes.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD284
Applications Flow Cytometry
Classification Monoclonal
Clone MTS510
Concentration 1.0mg/mL
Conjugate Unconjugated
Description TLR4/MD-2 Complex
Formulation No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
Host Species Rat
Immunogen Mouse Pro-B cell line Ba/F3 expressing transfected BALB/c mouse TLR4 and MD-2
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG2a κ
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