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CD29 Mouse anti-Human, NA/LE, Unlabeled, Clone: HUTS-21, BD

Catalog No. BDB556047 Shop All BD Biosciences Products
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BDB556047 0.5 mg
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Catalog No. BDB556047 Supplier BD Biosciences Supplier No. 556047

Description

Mouse Monoclonal Antibody

Reacts with the 130kDa integrin β1 subunit, CD29, that is expressed following cell activation as a heterodimeric complex with one of nine distinct α subunits, comprising the very late activation antigen (VLA) subfamily of adhesion receptors. The HUTS-21 β1 epitope is weakly expressed on resting lymphocytes, but is upregulated by TPA, Ca++ ionophore, or another CD29 antibody, TS2/16. This upregulation is Mn++ dependent and not supported by other divalent cations such as Ca++ and/or Mg++. The VLA receptors have a broad cellular distribution and interact with ligands like VCAm-1 and MAdCAM-1 during cell adhesion. They also interact with extra-cellular matrices including collagen, laminin, fibronectin and others. HUTS-21 antibody enhances adherence of TPA-activated lymphocytes to fibronectin. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD29
Applications Flow Cytometry
Classification Monoclonal
Clone HUTS-21
Concentration 1.0mg/mL
Conjugate Unconjugated
Description Integrin β1 Chain
Formulation No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
Host Species Mouse
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C
Isotype IgG2a κ
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For Research Use Only.

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