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CD294 (CRTH2) Rat anti-Human, PE, Clone: BM16, BD

Catalog No. BDB563665 Shop All BD Biosciences Products
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BDB563665 100 Tests
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Catalog No. BDB563665 Supplier BD Biosciences Supplier No. 563665
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Description

Rat Monoclonal Antibody

The BM16 monoclonal antibody specifically binds to CD294. CD294 is encoded by PTGDR2 (Prostaglandin D2 receptor 2) and is also known as CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells), GPR44 (G protein-coupled receptor 44), DL1R, and DP2. CD294 is a member of the G protein-coupled leukocyte chemoattractant receptor family. CD294 is expressed on Th2 cells and type-2 innate lymphoid cells (ILC2), but not Th1 type cells. CD294 is detectable on CD4+ T cells in fresh PBMC but not on B cells and NK cells. CD294 is also expressed on peripheral blood basophils and eosinophils, suggesting its involvement allergic reactions. Phenotypic analysis of CD4+ T cells expressing CRTH2 demonstrated that they were also CD45RA-negative and CD45RO+ and CD25+. These cells produce Th2- but little or no Th1-type cytokines upon stimulation with PMA and Ionomycin.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD294 (CRTH2)
Applications Flow Cytometry
Classification Monoclonal
Clone BM16
Conjugate PE
Description CRTH2; PTGDR2 ; Prostaglandin D2 receptor 2; DL1R; DP2; GPR44
Host Species Rat
Immunogen Human CRTH2 Transfected Cell Line
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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