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CD3 Rat anti-Mouse, NA/LE, Unlabeled, Clone: 17A2, BD

Catalog No. BDB562163 Shop All BD Biosciences Products
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BDB562163 0.5 mg
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Catalog No. BDB562163 Supplier BD Biosciences Supplier No. 562163
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Description

Rat Monoclonal Antibody

The 17A2 monoclonal antibody specifically binds to the T-cell receptor-associated CD3 complex that is expressed on many thymocytes and mature T lymphocytes. Plate-bound 17A2 antibody has been reported to induce IL-2 production by cultured T cells in the absence of accessory cells. The binding of the 17A2 antibody to T cells can be blocked by the anti-CD3e mAb 145-2C11. This suggests that the 17A2 antibody recognizes an epitope of the CD3 epsilon chain. In vivo treatment with 17A2 antibody has been reported to partially deplete T lymphocytes and temporarily down-modulates CD3 expression on T cells.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD3
Applications Flow Cytometry
Classification Monoclonal
Clone 17A2
Concentration 1.0mg/mL
Conjugate Unconjugated
Description CD3; CD3 epsilon; Cd3e; CD3ε; T3e
Formulation No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
Host Species Rat
Immunogen Alphadelta TCR-positive T-T hybridoma D1
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG2b κ
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