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Description
Monoclonal antibody APA1/1 reacts with the intracellular domain of the epsilon chain of the CD3 molecule (CD3- ε ). This antibody does not react with the extracellular region of CD3- ε . The assembly of the T cell antigen receptor (TCR)-CD3 complex has been suggested to take place by pairwise interactions of the CD3- ε subunit with either CD3- γor CD3- δ . These dimers then associate with the TCR heterodimer a/ β or γε . Other anti-CD3 antibodies (OKT3, WT31, UCHT1, Leu4) did not react with COS cells singly transfected with CD3- ε . This reagent could be useful for the study of T cell development or the study of conformational changes of CD3- ε upon ligand binding to TCR-CD3 complex.
Specifications
Specifications
| Antigen | CD3 ε |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Clone | APA1/1 |
| Conjugate | FITC |
| Formulation | Aqueous buffered solution containing BSA and ≤0.09% sodium azide. |
| Host Species | Mouse |
| Purification Method | Affinity Purified |
| Quantity | 100 Tests |
| Regulatory Status | RUO |
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For Research Use Only.
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