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CD30 Mouse anti-Human, Clone: MEM-268, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119412
DescriptionCD30 (Ki-1, TNF Receptor Superfamily Member 8) is a type I transmembrane glycoprotein of the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkin ft.s disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkin ft.s and Reed-Sternberg cells, CD30 is also found in some non-Hodgkin ft.s lymphomas (including Burkitt ft.s lymphomas), virus-infected T and B cells, and on normal T and B cells after activation. In T cells, CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that co-express CD45RO and the IL4 receptor. Soluble form of CD30 (sCD30) serves as a marker reflecting Th2 immune response. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. CD30 is a positive regulator of apoptosis, and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. CD30 is expressed by mononuclear cells in Hodgkin ft.s lymphoma, Reed Sternberg cells and most Anaplastic Large Cell Lymphomas (ALCL). CD30 is also expressed by embryonal carcinomas.
|Expression vector containing CD30 cDNA (booster suspension of THP-1 cell line).|
|Flow Cytometry, Immunohistochemistry (Paraffin)|
|PBS with 15mM sodium azide; pH 7.4|
|CD30 antigen, CD30L receptor, Ki-1 antigen, cytokine receptor CD30, lymphocyte activation antigen CD30, tumor necrosis factor receptor superfamily member 8|
|4° C, do not freeze|
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