CD337 (NKp30) Mouse anti-Human, PE, Clone: P30-15, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 558407

Catalog No. BDB558407

Description

The monoclonal antibody clone p30-15 reacts with CD337, also known as NKp30, a receptor found on the surface of natural killer (NK) cells. NK cells are large lymphoid cells discovered because of their ability to recognize and kill abnormal cells such as tumor and virally infected cells. NK cell immune responses are regulated by a balance of activating and inhibitory signals generated by cell surface receptors. Inhibitory receptors recognize MHC class I molecules on normal cells producing a negative signal to the NK cell. Loss of MHC class I expression in infected or transformed cells results in the loss of this negative signal leading to NK cell activation. In concert with the loss of inhibitory signals, activation signals via NK receptors such as NKp30, NKp44, NKp46, NKG2D, and NKp80 mediate the activation of NK cells. NKp30 cooperates with NKp46 and/or NKp44 in the induction of NK cell-mediated cytotoxicity against the majority of target cells.

Specifications

• Antigen: CD337
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: NCR3; Natural cytotoxicity triggering receptor 3; NKp30; MALS; LY117; 1C7
• Host Species: Mouse
• Quantity: 0.1 mg
• Research Discipline: Immunology
• Target Species: Human
• Isotype: IgG1 κ

• Applications: Flow Cytometry
• Clone: P30-15
• Conjugate: PE
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Human NKp30 e tracellular domain Transfected Cell Line
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

For Research Use Only.